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ra0001p125 | (1) | WCRB2014

BMP15 plus GDF9 and cAMP modulator promote EGF receptor signaling to increase oocyte developmental competence in porcine cumulus–oocyte complexes from small follicles

Sugimura Satoshi , Ritter Lesley J , Rose Ryan D , Thompson Jeremy G , Mottershead David G , Gilchrist Robert B

Introduction: Oocytes acquire developmental competence with progressive folliculogenesis. Cumulusoocyte complexes (COCs) from small antral follicles are commonly used in IVM but have inherent low competence and are poorly responsive to amphiregulin (AREG) which normally mediates oocyte maturation. Here we examined effects of bone morphogenetic protein 15 (BMP15), growth differentiation factor 9 (GDF9), and dbcAMP on the maturation and subsequent developmental competence ...

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BMP15 plus GDF9 and cAMP modulator promote EGF receptor signaling to increase oocyte developmental competence in porcine cumulus–oocyte complexes from small follicles

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